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In contrast, regulatory approval in Western countries remains limited: in the United States, glycyrrhizin is primarily recognized as a food sweetener rather than a therapeutic agent, while in Europe, its use is largely confined to traditional medicine and flavoring

J Pharmacol Exp Ther 303:468475 Koch-Weser J (1976) Drug therapy

Similarly, we observed robust induction of -H2AX and LC3B I/B II levels with GPX4 genetic knockdown (Supplemental Fig

We then performed principal component analysis (PCA) via RunPCA and selected 15 principal components (PCs)

In summary, although current studies suggest that ferroptosis plays a central regulatory role in the pathological sequence of PVLlinking hypoxiaischemia, inflammatory infiltration, and white-matter necrosisand provides a new mechanistic basis for understanding the pathway from periventricular iron accumulation to oligodendrocyte loss and motor developmental impairment, several essential gaps remain