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Beyond its central role in apoptotic regulation, the tumor suppressor protein 53 (p53) critically contributes to ferroptosis by suppressing SLC7A11 expression

Accessed 03 July 2020 Jeckel MA, Grant T, Saporito RA (2015) Sequestered and synthesized chemical defenses in the poison frog Melanophryniscus moreirae

And it does so without suppressing endogenous production

Hong and collaborators found that DPDPE promotes a tyrosine phosphorylation of DOR which would recruit and activate Src that in turn could phosphorylate and activate GRK2

Another approach is to design prodrugs that exploit the high GST expression levels found in drug resistant tumors and cells