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Chronic -secretase inhibition specifically reduces cholesterol levels in neurons, leading to decreased presynaptic neurotransmitter release probability and impaired synaptic transmission, despite an increase in synapse numbers

[DOI] [PubMed] [Google Scholar] 133.Coelho B.L., Rocha L.G., Scarabelot K.S., Scheffer D.L., Ronsani M.M., Silveira P.C., Silva L.A., Souza C.T., Pinho R.A

Nuclear factor kappa B (NF-B) is a rapidly induced stress-responsive transcription factor that may play an important role in arsenic-induced signal transduction, cell transformation and apoptosis [27]

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doi: 10.1002/pbc.30803

Scanlan BJ, Tuft B, Elfrey JE, Smith A, Zhao A, Morimoto M et al