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It remains reserved for severe cases unresponsive to medical management

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It impedes cell growth and proliferation by inhibiting key enzymes involved in DNA, RNA, and protein synthesis, exerting both anti-inflammatory and immunosuppressive effects

5a) The source of ROS and the mechanism by which these ROS drive possibly drive this proinflammatory phenotype therefore warrant further investigation

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Although prolonged GSH depletion induced triglyceride depletion and reduced epididymal adipose tissue in mice, it induced a sex-dependent requirement of NRF2 expression in the liver