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Moreover, the NF-B p52 functions in Th17 cells to mediate production of the proinflammatory cytokine GM-CSF, which is required for second wave of immune cell recruitment to the CNS and EAE pathogenesis [63] (Fig

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In later stages, the cancer may or may not grow through the walls of the colon or rectum, but will spread to lymph nodes, distant parts of the peritoneum (the inner lining of the abdominal cavity), or distant organs (such as the liver or lungs)

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