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FDX1 serves multiple roles in this process: It catalyzes the lipid acylation of pyruvate dehydrogenase and -ketoglutarate dehydrogenase, and enhances copper ion toxicity by converting Cu2+ to the more toxic Cu+ (184)

For some people, it goes away quickly

doi: 10.1016/s0140-6736(75)90856-9

Current understanding of COPD pathogenesis primarily focuses on airway inflammation, immune dysfunction, oxidative stress, and protease-antiprotease imbalance