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DILI in Patients with Disease State Certain disease conditions may predispose individuals to DILI due to alterations in host immune function, drug metabolizing enzyme activity, lower serum albumin, glutathione reserve in the liver and overall ability to scavenge chemically reactive metabolites that can induce hepatotoxicity

however, given the nature of the population, this may be unavoidable

doi: 10.1016/j.freeradbiomed.2019.12.007 221 JamillouxYEl JammalTVuittonLGerfaud-ValentinMKereverSSeveP

LP is one of the most strongly selected gene traits in recent human evolution and is observed frequently in populations with a long history of dairy consumption, making it an exemplary candidate of gene-diet co-evolution