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30 However, these are infrequent, mild and typically dose-related and can cease after reduction in the dose administered or removal of the drug

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Following the two week period, researchers may continue administering a maintenance dose of 1mg/daily, if necessary to achieve full or near-full recovery among test subjects

Sensorial neuropathy and other sensorial neuropathy syndromes which can be caused by long-term administration of high doses of pyridoxine improve gradually upon vitamin discontinuation

For example, long-term use of oral contraceptives may lower levels of Vitamin B2 (riboflavin) , while some diabetes and epilepsy drugs affect Vitamin B12 (cobalamin) levels