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If you have a high-stress life, high caffeine intake, or high alcohol intake, you may need extra B12

In their review, Doets et al

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Scientific publications describe its application in studies involving nicotinamide N-methyltransferase (NNMT), cellular metabolism, enzymology, and biochemical pathway investigations

Additionally, methylated quinolines such as 5-amino-1-methylquinolinium have been identified as NNMT inhibitors through ligand-based in silico methods and biological evaluations 203