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It is an extremely complicated process where a lot of internal and external factors are involved in both steps (Drubin et al., 1985

10.1021/bi050840w 55 JayasingheS

Quantitatively, haemoglobin and haemoglobin-haptoglobin complexes are likely to be the most significant extracellular sources of haem in vivo (Seale et al., 2006)

Thirty five % is excreted conjugated with sulfate and 3% conjugated with cysteine [11]

[PubMed: 4370423] 519

Case studies demonstrating successful resolution of reactive metabolite liabilities are abundant in the medicinal chemistry literature and often involve the following strategies: (a) removal of the functional group susceptible to bioactivation, (b) modulation of electronic character (e.g