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10.1016/j.phytochem.2006.05.012 22 CalmesB.Morel-RouhierM.Bataill-SimoneauN.GelhayeE.GuillemetteT.SimoneauP

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However, in the heart, hyperacetylation of LCAD and -hydroxyacyl-CoA dehydrogenase has been observed to increase FA oxidation.36 Furthermore, deletion of cardiac SIRT3 increased acetylation of these enzymes and FA oxidation.36 Studies have also assessed acetylation on Krebs cycle enzymes, but they are limited and contradictory, with findings suggesting opposing effects of acetylation on the activity of a single enzyme.33 , 34 It is important to consider differences between studies, such as the tissue from which the mitochondria are isolated, differences between in vitro and in vivo acetylation, and how acetylation is mediated, which may account for the variation in results

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Researchers analyze its structure and peptide-related interactions within experimental research models

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