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One of the key challenges is the compensatory upregulation of other enzymes, such as TDO2, which can maintain kynurenine production in the presence of IDO1 inhibitors ( Figure 1B ) (38)

11,12,13,14,15,16 Arrest in a capillary bed and subsequent extravasation is influenced by factors that control cancer cell motility and endothelial cell disjunction

Immune cells that mediate the initiation and progression of inflammatory responses consequently represent promising therapeutic targets for intervention in age-related immune dysfunction

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Available online at: (Accessed June 28, 2025)