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AML cells are much more sensitive to PARP inhibitors when NAD+ depletion is present because it not only prevents PARP-mediated repair of DNA single-strand breaks but also causes homologous recombination defective (HRD) phenotypes by down-regulating SIRT6s deacetylation activity, which results in hyperacetylation and transcriptional repression of the BRCA1 promoter region (121)

Phytomedicine 8:207212 Lin WH, Tsai MT, Chen YS, Hou RC, Hung HF, Li CH, Wang HK, Lai MN, Jeng KC (2007) Improvement of sperm production in subfertile boars by Cordyceps militaris supplement

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