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Older adults, who often suffer from decreased hydrochloric acid in the stomach, and individuals with gastrointestinal (GI) disorders may have lower absorption of B12.2,4 Vitamin B12 deficiency may be characterized by megaloblastic anemia, fatigue, weakness, constipation, loss of appetite, soreness of the mouth or tongue, and weight loss

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The combined effect: even when dietary B12 intake is adequate, absorption from food can drop to a fraction of what it was at 40

These are all processes involved in tissue repair and regeneration, [2] which is why the peptide attracted interest beyond gastroenterology