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These solutions are chloride-free (or low chloride) to enable chloride shift (influx of the weak acid bicarbonate in exchange for the efflux of the strong chloride)

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Docosahexaenoic acid appears to be important for central nervous system function.5-6 Cross-sectional studies have linked low DHA levels with dementia,7-10 while prospective studies have linked all-cause dementia and Alzheimer disease with decreased fish intake.11-14 Our hypotheses in this study were that plasma phosphatidylcholine (PC) DHA content is related to the risk of all-cause dementia and Alzheimer disease, as well as to dietary DHA and fish intake

Impairment can affect energy metabolism and nerve function

That may be a rational design for local GI exposure , where systemic bioavailability may not even be the primary objective

Dietary reference intakes for vitamin a, vitamin K, arsenic, boron, chromium, copper, iodine, Iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc