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Safety monitoring is also crucial while probiotics and FMT have been safe in trials so far, there is a theoretical risk of introducing infections or causing undesired immune reactions, especially in patients with immune dysfunction (like those on MS immunosuppressants)

Monitoring: Ongoing testing tracks how the body responds, allowing protocol adjustments as needed

Recent studies have also uncovered the regulatory role of non-coding RNAs (e.g., circCDYL [60], LncMIR210HG [142], circ-calm4 [145], circMyst4 [146], chromatin-associated circ RNA SCN8A [143]) in ferroptosis, revealing opportunities for RNA-based interventions

Improved range of motion and functional improvement usually show up around weeks 1-2

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