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Data Availability The datasets generated during the current study are available from the corresponding author on reasonable request

The fading of the observed initial growth inhibition is likely due to the lack of additional T-cell co-stimulation, the limited lifespan of the co-inoculated PBMCs and the absence of T-cell influx into the developing tumours, as would normally occur in an immunocompetent host

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Interestingly, the screening revealed the existence of an allosteric pocket close to the NADPH binding site, named the doorstop pocket since ligands binding at this site interfere with TR activity by hampering the opening movement needed to allow cofactor binding

and IEP, 0.67 (Fig