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In: "Mesenchymal Stromal Cells: Biology and Clinical Applications"

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But their translation into routine practice necessitates rigorous evaluation of safety, durability of efficacy, and patient heterogeneity-factors that remain insufficiently addressed to date ( 4.1 Liver-selective THR agonists for metabolic and fibrotic correction Emerging pharmacological strategies have increasingly targeted THR signaling, particularly in the treatment of NASH and progressive MAFLD (158, 159)

Another avenue is advanced surface engineering to create coatings that are selectively permeable to contaminants but act as a robust physical and chemical barrier to biological macromolecules, thus preventing the non-specific interactions that initiate toxicity.186 Fig