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[,] Effective alternative or additional therapy options must be investigated due to these conditions

Author contributions LH and HT designed and wrote the article

In addition, MPO activity was estimated using an MPO Detection Kit (Nanjing Jiancheng Bioengineering Institute, China)

The off-cycle is intended to keep the GH receptor responsive

Mutations that decrease the amount of functional MRP2 have also been associated with greater incidence of toxic liver injury and hepatotoxicity during administration of cytotoxic drugs 6,7,8,9