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The exact pathogenesis of ferroptosis has not yet been clarified

Johansson L

Fragmented oxidized mtDNA enters the cytosol where it activates NLRP3 inflammasome and generates the production of IL-1, IL-18, and cyclic GMP-AMP synthase-STING, inducing type I interferons and interferon-stimulated genes (Orekhov et al., 2023)

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Yang Y, Bazhin AV, Werner J, Karakhanova S

3.3.3 Duration of Action The modified pharmacokinetic profile of SAG may support less frequent dosing regimens than unmodified GSH, potentially enabling once-daily dosing to improve consumer compliance