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In the last few years, an increasing number of targets that induce or inhibit ferroptosis have been uncovered, but which of them provides the best therapeutic effect, which can be used in animal models or patients, and which can be easily handled chemically are still unclear

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Variables include: Age and baseline GHK levels Diet and overall nutrition Sleep quality and quantity Sun exposure and skin care habits Genetic factors affecting copper metabolism Concurrent health conditions Researchers who optimize supporting factors (sleep, nutrition, sun protection) typically report better outcomes than those relying solely on peptide administration

Consequently, the quality of evidence will be categorized into four different levels: high, moderate, low, and very low

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