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Also, treatment with Vardenafil has been shown to decrease DNA damage and oxidative stress, as well as to increase cGMP levels in aortic walls [24]

From structural analyses, it appeared that these dual biochemical properties originate from the existence of a certain variability in the 1-1 loop

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Although these therapies have shown many advantages in cardiac tissue repair by improving angiogenesis, reducing lesion size, and enhancing cardiac function, they still suffer from limitations such as the low survival rate of transplanted cells, poor cell retention, and lack of host tissue integrity