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Blood serum of anonymous donors was obtained from West-Tallinn Central Hospital (Estonia) and the study approval was obtained from Tallinn Medical Research Ethics Committee

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Additionally, another study demonstrated that AMPK is a negative switch of the Warburg effect in cell and animal models (160)

Additionally, excessive NO can break the balance of intracellular redox and trigger inflammatory reactions, resulting in muscle tissue damage and atrophy (Kaminski and Andrade, 2001)

Cellular redox homeostasis depends on the balance between the generation and elimination of ROS by several enzymes and antioxidants, and the imbalance of cellular redox homeostasis leads to oxidative stress, which imposes a substantial burden on cells [29, 30]