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To mitigate confounding from genetic differences, we created isogenic primitive and differentiated cell cultures then compared their pyrimidine synthesis programmes

Toxicol Lett 1999;104:13742

The activation of NRF2 by this mechanism enhances the transcription of genes involved in antioxidant defense and cystine/glutamate exchange, particularly those coding for components of the xCT antiporter (such as SLC7A11), which imports cystine in exchange for glutamate

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Iron is probably one of the most important metals sustaining critical physiological processes, but also with the potential to cause neurotoxicity when in excess

Its mechanism involves activating the AMPK/SIRT1 pathways and suppressing lipogenic regulators like PPAR and SREBP-1c, highlighting its potential as a therapeutic candidate for NAFLD (96)