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Across the 19 variants, only those in PNPLA3 - SAMM50 - PARVB gene complex showed statistically significant associations for higher fibrosis and MAS score with the highest risk for the PNPLA3 rs738409 SNP (Figure 1)

Freeze drying (FD) achieves high-quality products by sublimating water directly from the solid to vapor phase, maintaining heat-sensitive properties like vitamins due to the low drying temperature (92)

Neurosci Lett 469(3):3337 Gano LB, Liang LP, Ryan K, Michel CR, Gomez J, Vassilopoulos A et al (2018) Altered mitochondrial acetylation profiles in a kainic acid model of temporal lobe epilepsy

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The oral administration of Fusobacterium nucleatum significantly elevated the plasma triglyceride and cholesterol levels in ApoE / mice fed a high-cholesterol diet, promoting the onset and development of atherosclerosis 101

Parallel modulators such as brain-derived neurotrophic factor (BDNF) ( via tropomyosin receptor kinase B (TrkB)/AKT) and g protein-coupled receptor kinase 2 (GRK2) [which constrains p38-mitogen activated protein kinase (MAPK)] fine-tune the pathway in neural tissue, while AMPK provides an energy-status override that can suppress mTORC1 even when PI3K is active (Zhang HP