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Antiepileptic effects of antioxidant potent extract from Urtica dioica Linn

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doi: 10.1038/s41586-020-2588-y 12 NishigaMWangDWHanYLewisDBWuJC

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Targeted therapy against ROS A synthetic antioxidant regimen has been established with four main approaches: lipid-lowering, blood pressure-lowering, thiol supplementation, and enzyme replacement Statins block the mevalonate pathway by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, reduce Rac1 membrane translocation, thereby lowering ROS derived from NOX, while stabilizing eNOS mRNA, increasing NO bioavailability, and inhibiting various adhesion molecules, achieving a dual suppression of oxidative stress and inflammation [486]