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There are studies showing that TCR stimulation induces the generation of an enormous amount of ROS, thus resulting in the activation of transcription factors nuclear factor of activated T cells (NFAT), activator protein-1 (AP-1), and nuclear factor kappa light chain enhancer of activated B cells (NF-kB) (80)

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Compared with the blank group and the SF/HAMA group, the SF/HAMA/DDM group had a larger staining area, the staining intensity increased, the positive area widened with increasing DDM content, and the SF/HAMA/DDM-50 group presented the most pronounced increase

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Redox Responsive Hyaluronic Acid Nanogels for Treating RHAMM (CD168) Over-Expressive Cancer, Both Primary and Metastatic Tumors