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In high-fat-diet-induced insulin-resistant mice, treatment with methazolamide or imatinib significantly enhanced glucose tolerance, insulin sensitivity, and normalized fasting glucose, insulin levels, and HOMA-IR

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However, he quickly moves on, dealing far less with how the sense of smell integrates with emotions and far more on how this facial expression has become stylised as a visual signal of disdain, to be triggered in social settings even in the absence of an unpleasant smell