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Oxidative stress parameters were systematically assessed by measuring plasma catalase (CAT) activity, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), total antioxidant capacity (T-AOC), and the lipid peroxidation marker malondialdehyde (MDA) using standardized assay kits (Nanjing Jiancheng Bioengineering Institute, China)

doi: 10.1038/s41589-020-0483-3 125 HofmannKDukerMFinkTLichterPStoffelW

SkQ1 regulates expression of Nrf2, ARE-controlled genes encoding antioxidant enzymes, and their activity in cerebral cortex under oxidative stress

In addition, the blood and brain glutamate levels were positively correlated, suggesting that blood glutamate levels can be utilized to diagnose autism early

In doing so, it may damage the mt DNA and this may cause leakage of the mt DNA into the cytoplasm with then acts as a trigger for activation of innate immunity [34]

Through rescue experiments at both the mRNA and protein levels, it was confirmed that IGF1R may regulate the expression of LDHA through STAT3 activation