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Previ-ous reports showed that asparagine supplementation does not normalize the NAD + /NADH ratio when respiration is inhibited 8,16 , and that cytosolic MAS enzyme defects (GOT1 and MDH1) are better tolerated than those in the mitochondria (GOT2, MDH2) 22

Ethics statement The studies involving humans were approved by Ethical Committee of the Shahid Beheshti University of Medical Sciences (code: IR.GUMS.REC.1402.123)

Abstract This study aimed to evaluate the impact of piperine on experimental autoimmune uveitis (EAU)

& Bowser, R

10.1016/S0022-510X(09)70274-6 8

Conversely, despite the promising clinical use of colchicine to prevent inflammasome activation, we observed a significant increase in the IL-1 levels released by patient-derived PBMCs in vitro upon colchicine treatment ( Figure 3E )