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( Although lithiums prevention of neuro-inflammation may simply represent one of the multi-faceted mechanisms by which GSK-3 inhibition protects neurons, the above evidence also suggests that TLR4 is a direct target for lithium, upstream of GSK-3 (see Figure 1B)

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Mammals need Vitamin C, and with the exception of humans and guinea pigs, most mammals are able to make their own vitamin C from other nutrients in their body