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Safety and Tolerability: Where They Diverge Both compounds share the tolerability profile typical of appetite-suppressing metabolic peptides, but retatrutide carries additional signals that trace directly to its glucagon arm

Finally, more translational work is needed to determine whether AX can provide clinical benefits in conditions characterized by metabolic dysfunction and chronic low-grade inflammation, such as obesity, type 2 diabetes, or impaired muscle regeneration

Kirkland RA, Franklin JL

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American Diabetes Association