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Description

Physiol Entomol

Lofrumento, D

Similarly, in various degenerative diseases, including retinal degenerative diseases, age-related heart failure, and intervertebral disc degeneration, LCN2 promotes intracellular iron accumulation, mitochondrial dysfunction, and ferroptosis by activating the inflammasome via cGAS and STING1 and binding to its receptor SLC22A17, thereby accelerating degenerative processes (Gupta et al