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FASEB J 17:22022208 Porter NA, Caldwell SE, Mills KA (1995) Mechanisms of free radical oxidation of unsaturated lipids

Mast cell serine proteases, tryptase, chymase, and carboxypeptidase, further contribute to mast cell degranulation (161)

CRC stem cells have higher levels of cysteine, GSH, and SLC7A11 and, therefore, exhibit lower levels of ROS as compared to CRCs

When viewed in this context, it led us to ask whether parkin-dependent, redox-based mechanisms could explain heretofore unresolved findings from unbiased, proteomic-based investigations of parkin-deficient mice