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In both healthy and hyperglycemic rats, the administration of extract did not stimulate an increase in insulin levels, ruling out insulin secretion as one of the mechanisms contributing to the hypoglycemic effect when consumed orally

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In vitro and in vivo studies demonstrated Ru SA+AC had the biosafety, RONS scavenging ability, as well as mitochondrial protection, inflammation inhibition, and reduced apoptosis, thereby delaying OA

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