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Endosomal-lysosomal dysfunctions in Alzheimers disease: pathogenesis and therapeutic interventions

T H 2 cells secrete large amounts of interleukin-4 and associated cytokines that promote antibody production by B cells

Gross MI, Demo SD, Dennison JB, Chen L, Chernov-Rogan T, Goyal B, Janes JR, Laidig GJ, Lewis ER, Li J, Mackinnon AL, Parlati F, Rodriguez ML, Shwonek PJ, Sjogren EB, Stanton TF, Wang T, Yang J, Zhao F, Bennett MK

Mutational analysis indicated that the binding is strongly impeded when the KKK 230-232 motif in WASP is replaced by either uncharged or negatively charged amino acids 23,39

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Elevated concentrations of zinc in seminal fluid can, however, negatively impact the acrosome response generated by spermatozoa-zona pellucida binding in males with normal sperm parameters [127]