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Tohgi et al

These receptor pairs bind to specific DNA motifs called retinoic acid response elements and act like switches that turn certain genes on or off

reference preparation (R): dabigatran etexilate capsule (trade name Pradaxa, Boehringer Ingelheim International GmbH), specification: 150 mg per capsule, product batch number 105464 (Dispensing lot number E11747)

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NET-containing guanylated peptides can be internalized by FLSs through the TLR9 pathway, elevating the inflammatory phenotype of FLSs and upregulating the expression of major histocompatibility complex class II molecules, which subsequently produce autoantibodies by presentation to Ag-specific T-cells (168)

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