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SPRINT Research Group

6,10 Acute altitude illnesses (e.g., AMS, HACE, and HAPE) result from inadequate physiological adaptation to hypobaric hypoxia, whereas chronic conditions such as HAPH and CMS reflect the pathological consequences of prolonged or excessive adaptive responses

The therapeutic window for inhibiting GGT as a cancer therapy is potentially large, as sustained inhibition of GGT activity did not induce any overt toxicities