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The transcellular crossing of the epithelium exploits different components of the host intracellular trafficking system

Of these, lutein, zeaxanthin, and lycopene are non-provitamin A carotenoids due to no conversion, but -carotene, -carotene, and -cryptoxanthin are provitamin A carotenoids since the human body can convert them to retinol [146]

The latter form can act as a responder element sensitive to the intracellular redox status which also helps to determine the intracellular localization of the protein [203,204,205]

doi: 10.1038/s41420-022-01141-y 388 LiaoQLiYCuiMLiuM