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doi: 10.1038/s41564-020-00816-5 128

Standard protocol (250mcg twice daily) = 10 days

Furthermore, TET activity at promoter CGIs in stem cells may be counteracted by vitamin C-mediated co-activation of the H3K36 demethylase JHDM1b (KDM2B), which removes gene body H3K36me2/3 marks leading to p16 INK4a /p19 ARF gene silencing (He et al., 2008