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The major enzyme superfamilies comprise cytochrome P450 monooxygenases (P450s), glutathione S-transferases (GSTs), carboxylesterases (COEs), ATP-binding cassette (ABC) transporters, and UDP-glycosyltransferases (UGTs) [5, 26, 36-39] (Figure 2)

Those that develop acute liver failure can still recover spontaneously, but may require transplantation if poor prognostic signs such as encephalopathy or coagulopathy is present (see King's College Criteria)

It fades dark spots and other skin discolourations and effectively lightens and moisturises the face and body

The clearest hypothesis is that GSH synthesis is required for liver function

Commensal microbiota regulates skin barrier function and repair via signaling through the aryl hydrocarbon receptor

Glutathione is a tripeptide molecule, meaning it is constructed from three specific amino acids: glutamate, cysteine, and glycine