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In these contexts, astrocytes may shift from a neuroprotective role to one that exacerbates neuronal dysfunction, potentially due to downregulated expression of lactate dehydrogenase A (LDHA), a key glycolytic enzyme, which impairs lactate shuttling by inhibiting large conductance Ca 2+ activated potassium channel (BK channel)-mediated neuronal hyperpolarization (Yao et al., 2023)

Ziegler RG, Fuhrman BJ, Moore SC, Mattews CE

Bitter and sweet taste receptors regulate human upper respiratory innate immunity

ER stress and UPR activation in glioblastoma: identification of a noncanonical PERK mechanism regulating GBM stem cells through SOX2 modulation

G., Plomp, J

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