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By providing a supply of glutamate (GLU), glutamine is also indirectly involved in many metabolic reactions, such as the production of glutathione and the generation of energy in the citric acid cycle (both explained earlier)

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However, the role of mitophagy regulators such as PINK1/PRKN, BNIP3, and NIX in pancreatic tumorigenesis and progression is dynamic and intricate, as demonstrated in transgenic PDAC mouse models [53, 58]