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In addition, some OPs like CPF can also act via different signaling pathways, and future work should focus on inhibiting the role of different pathways in OP-induced neurological symptoms

Studies have shown that conditional loss of AMPK in the mouse uterus results in failure of scarless endometrial regeneration after delivery and severe endometrial fibrosis, leading to embryo implantation failure and reduced fertility (49)

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Therefore, the pro-apoptotic effect of tamoxifen is partially dependent on the inhibition of FLIP expression and inhibition of pAkt and stimulation of caspase activity in vivo and in vitro, respectively [87]