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Ethics declarations Ethics approval and consent to participate This animal experiment was approved by the Ethics Committee of Chengdu University of Traditional Chinese Medicine and carried out in strict accordance with the guidelines

The cDNA samples were diluted 20-fold and used as qRT-PCR templates

Biodistribution studies using ICP-MS and ex vivo fluorescence imaging revealed significant accumulation of the nanoplatform in both the substantia nigra and striatum after intravenous injection (Fig

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Interestingly, antibiotic treatment aiming to remove gut microbiota prevented the development of CCI-induced mechanical and thermal hyperalgesia