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Appendices Appendix 1: Literature Search Strategies Literature Search - Vitamin B12 Economic Evidence-Based Analysis Search date: June 3, 2013 Databases searched: OVID MEDLINE, MEDLINE In-Process and Other Non-Indexed Citations, EMBASE

Erythrocytes containing a small amount of reduced glutathione are relatively easily destroyed

Materials Today Communications, 28 , Article 102561

Ischemia-induced oxidative stress and inflammation worsen epithelial damage, which leads in an increased permeability of the intestinal lining, allowing the transfer of bacteria, their products, and toxins from the gut lumen into the circulation (Liao et al., 2022)

Although this study focused on methodological validation using isolated and purified clinical strains, the demonstrated high sensitivity, broad detection range, and robust anti-interference performance suggest potential for application to complex clinical samples like whole blood

Koch & Reimer, 2012)