glutathione conjugation spontaneous Triggered Cascade Degradation of an Amphiphilic Poly(disulfide)–Drug Conjugate and Targeted Release Formation of glutathione S -conjugates

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Wahid F, Zhao X, Zhao X, et al

The morphine molecule has both an alcoholic hydroxyl group (-OH) on the 6 position and a phenolic hydroxyl (-OH) group on the 3 position of the aromatic or benzenoid ring

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In db/db mice, CGA exhibited effects comparable to metformin, improving glucose tolerance and reducing hepatic lipogenesis via upregulation of -oxidation-related genes (CPT1a, ACOX1) and antioxidant enzymes (SOD1, SOD2, GPX1), as well as modifying gut microbiota composition [6]

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