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In the context of tumor immune microenvironment remodeling, the SSP induces an immunosuppressive phenotype, promotes M2-type macrophage polarization, sustains high PD-L1 expression, impairs the cytotoxic function of CD8 + T cells, and compromises the therapeutic efficacy of CAR-T cells

doi: 10.1111/exd.13115 103 RoderoMPHodgsonSSHollierBCombadiereCKhosrotehraniK

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10.1016/j.ejphar.2017.05.003 201 ZhuanB.WangX.WangM