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Despite advances in diagnosis and treatment, the overall survival rates for patients with GI tumors remain unsatisfactory due to tumor heterogeneity, frequent diagnosis at advanced stages, and the prevalence of primary or acquired resistance to conventional chemoradiotherapy, targeted therapy, and even immunotherapy [12,13,14]

and (b) it might induce a dynamic switching behavior that is useful in triggering signaling pathway(s) able to overcome metabolic stress maintaining cellular energy homeostasis (i.e

Curcumin ameliorates functional and structural abnormalities in cisplatin-induced neuropathy

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