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More recently, it has been suggested that NO from GSNO may be converted to SNO-Hb prior to its release from RBCs (47), perhaps due to the ability of S-nitrosothiols to react with ferrous heme groups in oxyHb

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While evidence for these claims is still emerging and must be interpreted cautiously, the convenience and ease of administration through our semisolid gel formulation might make it an attractive option for those seeking to trial such alternative uses